daocrat
e
s bio

exploring the ‘whole’ picture of histamine pathology
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Our Aspiration

To provide a treatment solution for the broad population of patients suffering from diseases associated with mast cell activation through a comprehensive understanding of the role histamine plays in these diseases. We are developing a potent and highly specific agent that rapidly and completely degrades histamine. Scientific evidence indicates that our therapeutic approach could have major positive impact for patients suffering from diseases associated with mast cell activation and excessive histamine release.

Target

Our Story

The name Daocrates Bio finds its origin in the convergence of the wisdom of the ancient philosopher Socrates and the strength inherent in the biological power of the enzyme diamine oxidase (DAO). A dual heritage –’DAO’, representing our focus on pioneering research about histamine and the enzyme that degrades it, together with ‘kratos’, the Greek word for power.

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Our Technology

Our Technology

Through the introduction of two unique mutations, we have developed a recombinant form of human diamine oxidase (rhDAO) which offers striking and persistent histamine degradation, with a pharmacological profile suitable for both acute and chronic use.

Development Overview

Our early clinical plan includes an integrated study involving both healthy volunteers and patients. This will define human pharmacology, confirm the pharmacodynamic effect of rhDAO, and allow rapid transition into a registration-directed clinical program. First data in patients with poorly controlled mast cell disease are anticipated to demonstrate immediate clinical benefit. The clinical opportunity is significant in rarer mast cell diseases, those associated with acute mast cell degranulation, as well as a broad range of inflammatory, allergic, and autoimmune diseases.
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